A Dominant Epistatic Gene which Inhibits Cellular Susceptibility to RSV(RAV-O)

Abstract

Summary The susceptibility to infectious RSV(RAV-O) of pure-bred and incross-bred chick embryos from the inbred Reaseheath c and i lines was studied, and a genetic hypothesis is proposed to explain the observed segregation of susceptible and resistant embryos. The results suggest (1) the presence of a dominant autosomal gene for susceptibility to RSV(RAV-O), designated es , in the 1 line, and of its recessive allele, es , in the c line, and (2) the presence in the 1 line of an unlinked dominant, autosomal epistatic gene Ie , which inhibits the expression of es , and of its recessive allele, ie , in the c line. The two loci are designated ‘tumour virus e (tve)’ and ‘inhibitor e (Ie )’.