Cocaine Decreases Cortical Cerebral Blood Flow but Does Not Obscure Regional Activation in Functional Magnetic Resonance Imaging in Human Subjects
- 1 July 1998
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 18 (7), 724-734
- https://doi.org/10.1097/00004647-199807000-00003
Abstract
The authors used functional magnetic resonance imaging (fMRI) to determine whether acute intravenous (IV) cocaine use would change global cerebral blood flow (CBF) or visual stimulation-induced functional activation. They used flow-sensitive alternating inversion recovery (FAIR) scan sequences to measure CBF and blood oxygen level-dependent (BOLD) sensitive T2* scan sequences during visual stimulation to measure neuronal activation before and after cocaine and saline infusions. Cocaine (0.6 mg/kg IV over 30 seconds) increased heart rate and mean blood pressure and decreased end tidal carbon dioxide (CO2). All measures returned to baseline by 2 hours, the interinfusion interval, and were unchanged by saline. Flow-sensitive alternating inversion recovery imaging demonstrated that cortical gray matter CBF was unchanged after saline infusion (–2.4 ± 6.5%) but decreased (–14.1 ± 8.5%) after cocaine infusion (n = 8, P < 0.01). No decreases were detected in white matter, nor were changes found comparing BOLD signal intensity in cortical gray matter immediately before cocaine infusion with that measured 10 minutes after infusion. Visual stimulation resulted in comparable BOLD signal increases in visual cortex in all conditions (before and after cocaine and saline infusion). Despite a small (14%) but significant decrease in global cortical gray matter CBF after acute cocaine infusion, specific regional increases in BOLD imaging, mediated by neurons, can be measured reliably.Keywords
This publication has 34 references indexed in Scilit:
- Automated shimming at 1.5 t using echo‐planar image frequency mapsJournal of Magnetic Resonance Imaging, 1995
- Borders of Multiple Visual Areas in Humans Revealed by Functional Magnetic Resonance ImagingScience, 1995
- Methylphenidate decreases regional cerebral blood flow in normal human subjectsLife Sciences, 1994
- Respiratory patterning following cerebral ventricular administration of cocainePharmacology Biochemistry and Behavior, 1993
- Rapid Automated Algorithm for Aligning and Reslicing PET ImagesJournal of Computer Assisted Tomography, 1992
- Time course EPI of human brain function during task activationMagnetic Resonance in Medicine, 1992
- Echo‐planar time course MRI of cat brain oxygenation changesMagnetic Resonance in Medicine, 1991
- Cerebral hemodynamic response to mental activation in normo- and hypercapnia.Stroke, 1980
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960
- THE ASSESSMENT OF ANXIETY STATES BY RATINGPsychology and Psychotherapy: Theory, Research and Practice, 1959