Effect of Vitamin B12, Unsaturated Fat and Hydrolyzed Glucosecycloacetate on Bile Acid Excretion in Experimental Hyperlipemia.

Abstract

Bile acid excretion was studied in rats fed unsaturated, saturated and mixed (unsaturated and saturated) fats at 20% level. It was observed that saturated fat diminished the bile acid excretion in the feces and caused elevation of plasma cholesterol; whereas the animals receiving unsaturated and mixed fat diets brought about a decrease in the plasma cholesterol contents and an increase in the excretion of bile acids. Vitamin B12 and hydrolyzed glucose-cycloacetoacetate (GCA,h) when injected to saturated fat fed animals, also showed increased elimination of bile acids in the feces, thus indicating their important role in increasing the metabolism of cholesterol in the living system through its conversion to bile acids.