PROFOUND VASCULAR CHANGES INDUCED IN THE UTERUS OF THE CASTRATED RABBIT BY COMBINATIONS OF ESTRADIOL BEN2OATE AND PROGESTERONE

Abstract

Estradiol benzoate and progesterone when suitably combined and injected into castrated rabbits will cause widespread vascular changes in the endometrium and myometrium including uterine hemorrhage. In castrated rabbits estrogen when suitably combined with progesterone will cause a progestational reaction; or it will inhibit the progestational effect of progesterone or again it will lead to profound vascular changes in the uterus. These reactions depend exclusively on the absolute amts. of estradiol and progesterone employed. Within limits the amts. of estradiol and progesterone required to produce vascular changes in the uterus are inversely proportional to one another.