Augmentation of cell-mediated cytotoxicity to a rat lymphoma. I. Stimulation of non-T-cell cytotoxicityin vivo by tumour cells
- 15 August 1979
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 24 (2), 235-243
- https://doi.org/10.1002/ijc.2910240216
Abstract
The injection of a syngeneic Gross-virus-induced lymphoma into W/Fu rats induced peaks of cytotoxicity in the spleen attributable to non-T cells and T cells 3 and 10 days later, respectively. The conditions required for augmenting the cytotoxicity of the non-T cells in various lymphoid compartments (shown elsewhere to closely resemble NK cells) were analysed using the ip and iv routes of inoculation and a variety of tumour cells including those normally susceptible or resistant to lysis by NK cells in vitro. Using an ip inoculation of W/FuG-1 cells (a tumour susceptible to lysis by NK cells), a short-lived, 3-fold increase in cytotoxicity was observed in the spleen at day 3 and a 5-fold increase in the PEC at day 5. Cytotoxicity in other lymphoid organs remained unchanged. Tumours resistant to lysis by NK cells also stimulated cytotoxicity in the spleen or PEC, although the effect depended on the dose and route of inoculation used, and depression of cytotoxicity was observed under some conditions.This publication has 24 references indexed in Scilit:
- Augmentation of cell-mediated cytotoxicity to a rat lymphoma. II. Characterization of the non-T cytotoxic cells stimulatedin vivo by tumour cells as natural killer cellsInternational Journal of Cancer, 1979
- Enhanced NK cell activity in mice injected with interferon and interferon inducersNature, 1978
- Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivoNature, 1977
- Augmentation of natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic target cellsInternational Journal of Cancer, 1977
- Decreased “natural killer” effect in tumor‐bearing mice and its relation to the immunity against oncorna virus‐determined cell surface antigensEuropean Journal of Immunology, 1976
- Secondary Cell-Mediated Cytotoxic Response to Challenge of Rats With Syngeneic Gross Virus-Induced LymphomaJNCI Journal of the National Cancer Institute, 1976
- Studies on a gross‐virus‐induced lymphoma in the rat. III. Optimisation, specificity and applications of the in vitro immune responseInternational Journal of Cancer, 1976
- Natural Cytotoxic Reactivity of Rat Lymphocytes Against Syngeneic Gross Virus-Induced Lymphoma2JNCI Journal of the National Cancer Institute, 1976
- „Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotypeEuropean Journal of Immunology, 1975
- The effect of specific anti-rat thymocyte serum on cell-mediated tumor immunity and other lymphocyte functionsCellular Immunology, 1974