Synthesis of (pGlu‐5, MePhe‐8, Sar‐9) Substance P (5–11) (DiMe‐C7) using a polyacrylamide resin and biological activity on guinea pig ileum and tracheal smooth muscle
- 1 February 1987
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 29 (2), 170-176
- https://doi.org/10.1111/j.1399-3011.1987.tb02243.x
Abstract
DiMe-C7 (pGlu-Gln-Phe-MePhe-MeGly-Leu-MetNH2), a metabolically stable analogue of Substance P, was prepared by solid-phase peptide synthesis using a polyacrylamide resin and a labile anchorage derived from glycolic acid. Myotropic activities in guinea pig ileum (EC50 = 4.0 .+-. 1.5 10-8 M) and guinea pig trachea (EC50 = 8.6 .+-. 3.5 10-8 M) are discussed in comparison with the corresponding activities of Substance P.Keywords
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