Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
- 4 August 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5925), 412-417
- https://doi.org/10.1038/304412a0
Abstract
The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.Keywords
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