HIF-1 and tumour radiosensitivity
Open Access
- 30 May 2006
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 95 (1), 1-5
- https://doi.org/10.1038/sj.bjc.6603201
Abstract
Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.This publication has 84 references indexed in Scilit:
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