Abstract
10 compounds were tested in respect of their chemo-therapeutic actions on mice infected with haemolytic streptococci, pneumococci, staphylococci or Bacillus aertrycke. The antibacterial actions in vitro of these compounds were also examined. 3-Nitro-4-hydroxyl-benzenesulphonamide has a marked curative effect on streptococcal septicaemias in mice. The low toxicity of this compound suggests that it should be investigated on a wider scale. Diacetyldiamino-diphenylsulphide delays the death of mice infected with staphylococci. Under the conditions of experimentation, no correlation could be established between the action of these compounds in vitro and their chemotherapeutic activity on infected mice. The important action of these compounds on the organisms was evidently not one of gross toxicity, but it involved a damaging of the defences which normally protected the organisms from the bactericidal processes of the body.