Three-receptor, clonal expansion model for selection of self-recognition in the thymus
- 1 February 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 283 (5747), 527-532
- https://doi.org/10.1038/283527a0
Abstract
The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.Keywords
This publication has 49 references indexed in Scilit:
- Specific adsorption of H-2-restricted cytotoxi T cells to macrophage monolayers.The Journal of Experimental Medicine, 1978
- T-cell inhibition of humoral responsivenessCellular Immunology, 1978
- In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.The Journal of Experimental Medicine, 1978
- Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.The Journal of Experimental Medicine, 1978
- On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?The Journal of Experimental Medicine, 1978
- Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNACell, 1978
- Evidence for an H–2/viral protein complex on the cell surface as the basis for the H–2 restriction of cytotoxicityNature, 1977
- Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.The Journal of Experimental Medicine, 1975
- Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.The Journal of Experimental Medicine, 1975
- Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitisNature, 1974