The literature of malignant disease of the larynx is so voluminous that any presentation should have a bearing only on the as yet inconclusively determined phases of the subject, especially those that seem to call for revision of opinion. We have therefore analyzed our data with a view to determining what light they throw on the following questions: Is the physician justified in limiting the use of irradiation to cases in which operation is contraindicated? Where shall the line be drawn between cases for operation and cases for irradiation? What is the bearing of the degree of malignancy on the choice between operation and irradiation? Is it justifiable to do a laryngectomy for a small growth in the anterior commissure even if the degree of malignancy is high? In view of the later improvements in the technic of irradiation is the surgeon not justified in