The highlighted article brings together research on the site and mechanism of endocrine-disrupting chemicals that have the potential to have a significant impact on human health and research on obesity, which is known to seriously affect human health. The effect of exposure to endocrine-disrupting chemicals on the initiation or exacerbation of obesity, which may significantly alter the perception of the etiology of obesity and impact intervention and prevention efforts, is an important emerging area needing even further research emphasis.