Kinetics of the Histological Changes in Lymphoid Organs and of the T-Cell Inducing Capacity of Serum in Mice Treated with Imuthiol® (Sodium Diethyldithiocarbamate)

Abstract

Sodium diethyldithiocarbamate (Imuthiol^>) triggers in mice an increased production of T-cell recruiting factors and an early and prolonged hyperplasia in the T-cell dependent areas of peripheral lymphoid organs, partially independent from thymus modification. The data confirm previous findings on the role of an extrathymic factor and are consonant with the notion of a feedback regulation to control T-cell differentiation.