Accumulation of ergosta‐8,14‐dien‐3β‐ol bySaccharomyces cerevisiae cultured with an azasterol antimycotic agent
- 1 August 1977
- Vol. 12 (8), 666-668
- https://doi.org/10.1007/bf02533762
Abstract
15-Aza-24-methylene-D-homocholesta-8,14-dien-3β-ol, an antimycotic agent, at a concentration of 75 ng/ml inhibited ergosterol biosynthesis inSaccharomyces cerevisiae strain 3701 B resulting in the accumulation of an unusual sterol. Experimental data presented indicate that this sterol is ergosta-8,14-dien-3β-ol. The accumulation of the compound is supportive of current models of biosynthetic pathways for sterols in yeast and is consistent with inhibition by the azasterol of the Δ14 sterol reductase.This publication has 21 references indexed in Scilit:
- The induced biosynthesis of 7-dehydrocholesterols in yeast: potential sources of new provitamin D3 analogsCanadian Journal of Biochemistry, 1976
- Inhibition of enzymatic reduction of Δ14‐double bond of 5α‐cholesta‐8,14‐dien‐3β‐ol and 5α‐cholesta‐7,14‐dien‐3β‐ol by AY‐9944Lipids, 1975
- New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization.The Journal of Antibiotics, 1975
- Effects of triparanol and AY‐9944 upon sterol biosynthesis inChlorellaLipids, 1974
- Sterol Transmethylation during Aerobic Adaptation of YeastEuropean Journal of Biochemistry, 1974
- Structure of antibiotic A25822B, a novel nitrogen-containing C28-sterol with antifungal properties.The Journal of Antibiotics, 1974
- Biosynthesis of terpenes and steroidsBioorganic Chemistry, 1973
- Biosynthesis of ergosterol in yeast. Evidence for multiple pathwaysJournal of the American Chemical Society, 1973
- The inhibitive effects of azasterols on sterol metabolism and growth and development in insects with special reference to the tobacco hornwormLipids, 1971
- Ultraviolet Absorption of Steroids.Chemical Reviews, 1953