Acid Responses of Denervated Fundic (Heidenhain) Pouches to Meals Compared with Those to Histamine and Pentagastrin

Abstract

Gastric acid responses to meals were compared with those to histamine and pentagastrin in 3 dogs with Heidenhain pouches. Large single feeds resulted in acid outputs that were approximately equal to the maximal response to histamine. The maximal acid response to pentagastrin was less than 50% of that to the meal or to the maximal dose of histamine. It is suggested that combinations of endogenously released stimuli (in response to a meal) can produce a potentiated gastric response which exceeds that produced by pentagastrin (exogenous gastrin) alone.