Effect of Rowachol on biliary lipid secretion and serum lipids in normal volunteers.
- 1 January 1985
- Vol. 26 (1), 32-37
- https://doi.org/10.1136/gut.26.1.32
Abstract
The effect of Rowachol (200 mg tid), an essential oil preparation, on biliary lipid secretion and serum lipids was measured in six healthy male volunteers before and after four weeks of treatment. Biliary cholesterol and phospholipid secretion increased significantly from 113 +/- 36 (SD) mumol/h to 155 +/- 52 mumol/h (p less than 0.05) and from 409 +/- 145 mumol/h to 587 +/- 185 mumol/h (p less than 0.05), respectively. Bile acid secretion increased from 1519 +/- 662 mumol/h to 2287 +/- 1175 mumol/h (p greater than 0.05 and greater than 0.10). This marked increase in biliary lipid secretion was not followed by a change in molar composition of biliary lipids and lithogenicity of bile. Serum cholesterol and triglycerides declined from 4.9 mmol/l to 4.1 mmol/l (p less than 0.05) and from 1.2 mmol/l to 0.9 mmol/l (p less than 0.05) respectively. The ratio of high-density-lipoprotein cholesterol to total cholesterol increased from 0.22 to 0.31 (p less than 0.05). Although it has been shown previously that Rowachol could dissolve cholesterol gall stones the present results indicate that Rowachol alone has only weak litholytic properties, at least in normal volunteers, but might have several advantages when combined with chenodeoxycholic or ursodeoxycholic acid.This publication has 44 references indexed in Scilit:
- Adjunct to bile-acid treatment for gall-stone dissolution: low-dose chenodeoxycholic acid combined with a terpene preparation.BMJ, 1981
- Treatment of biliary duct stones with a terpene preparation.BMJ, 1981
- Elevation of serum high density lipoprotein cholesterol by Rowachol, a proprietary mixture of six pure monoterpenesAtherosclerosis, 1980
- Biliary lipid composition during treatment with different hypolipidaemic drugsEuropean Journal of Clinical Investigation, 1979
- Rowachol--a possible treatment for cholesterol gallstones.Gut, 1979
- Gall stone dissolution in man using an essential oil preparation.BMJ, 1979
- The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.JCI Insight, 1978
- The use ofd-limonene preparation as a dissolving agent of gallstonesDigestive Diseases and Sciences, 1976
- Effect of phenobarbital on bile flow and bile salt excretion in the ratNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1971
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJCI Insight, 1955