THE RADIOIMMUNOASSAY OF TRICYCLIC ANTIDEPRESSANTS
Open Access
- 1 August 1976
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 3 (4), 561-565
- https://doi.org/10.1111/j.1365-2125.1976.tb04875.x
Abstract
1 An antiserum to nortriptyline has been produced in a sheep against a nortriptyline-bovine serum albumin conjugate. The conjugate was prepared using the reagent N-(4-bromobutyl) phthalimide followed by a carbodiimide reaction to link the hapten to the carrier protein. 2 The antibodies produced were shown to be specific for the tricyclic group of drugs. 3 The sensitivity of the radioimmunoassay developed is currently limited by the lack of a high specific activity label. The possibilities of developing a radioimmunoassay for nortriptyline in plasma are discussed.Keywords
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