The Blood-Cerebrospinal Fluid Barrier in Man
- 1 March 1961
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 4 (3), 318-322
- https://doi.org/10.1001/archneur.1961.00450090084012
Abstract
The concept of a barrier between blood and cerebrospinal fluid (CSF) has its origins in the many observations concerning the relative exclusion of certain drugs from the fluids of the central nervous system. A standardized technique was developed for a study of the quantitative aspects of transfer of drugs or metabolites across the blood-cerebrospinal fluid barrier in the dog.1 These drug distribution studies indicated that the plasma-CSF barrier is less of a special barrier than had been realized, and that, as far as the behavior of certain organic compounds, it would appear to have properties similar to other biological membranes. As with other membranes, the primarily lipoid nature of this barrier has been noted.1-3 Drugs which enter CSF rapidly and extensively are in general lipoid soluble and undissociated at body pH. Those drugs excluded from CSF are lipoid insoluble and dissociated at body pH since ionized moieties doKeywords
This publication has 5 references indexed in Scilit:
- THE ROLE OF pH GRADIENT IN THE DISTRIBUTION OF AMMONIA BETWEEN BLOOD AND CEREBROSPINAL FLUID, BRAIN AND MUSCLE*JCI Insight, 1959
- DISTRIBUTION OF DRUGS BETWEEN BLOOD AND CEREBROSPINAL FLUID - GENERAL METHODOLOGY AND EFFECT OF PH GRADIENTS1959
- Acid-Base Relations Between Spinal Fluid and Arterial Blood With Special Reference to Control of VentilationJournal of Applied Physiology, 1958
- A comparative study of the aqueous humour and cerebrospinal fluid in the rabbitThe Journal of Physiology, 1955
- THE ESTIMATION OF ANTIPYRINE IN BIOLOGICAL MATERIALSJournal of Biological Chemistry, 1949