METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES I. Synthesis on a Phenolic Resin Support†
- 1 September 1979
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 14 (3), 177-185
- https://doi.org/10.1111/j.1399-3011.1979.tb01923.x
Abstract
An efficient synthesis of methionine enkephalin using a phenolic resin support is described. Analogues modified at their C-termini, such as peptide acids, amides, methyl esters and compounds formed by their reduction, were prepared conveniently from common peptide phenyl ester resins. The resin was used in the synthesis of complex isosterically modified analogues designed to investigate the role the peptide backbone plays in receptor interaction. Free hexapeptide phenyl ester resins underwent intramolecular aminolysis liberating the corresponding cyclic peptides.Keywords
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