The role of the carotid body in mediating the cerebrovascular response to altered arterial carbon dioxide tension.
- 1 January 1976
- journal article
- abstracts
- Published by Wolters Kluwer Health in Stroke
- Vol. 7 (1), 72-76
- https://doi.org/10.1161/01.str.7.1.72
Abstract
The role of the carotid bifurcation chemoreceptors in mediating the cerebrovascular response to altered arterial PCO2 has been suggested to be large. In the present study the cerebrovascular response to raised PCO2 was measured in a group of baboons before and after bilateral inactivation of the carotid bodies. The results suggest that these chemoreceptors do play a part in the cerebral vasodilator response to raised PCO2. The role of the carotid body, however, appears to be relatively minor as it only accounted for +/- 40% of the total response and became significant only at arterial PCO2 levels of more than 50 mm Hg. It is postulated that the peripheral chemoreceptors in the carotid bifurcation mediate part of the cerebrovascular response to altered PaCO2 but the role is quantitatively small.Keywords
This publication has 7 references indexed in Scilit:
- Evidence for cholinergic dilatatory receptors in pial arteries of catsPflügers Archiv - European Journal of Physiology, 1974
- Respiratory recovery from CO 2 breathing in intact and chemodenervated awake dogs.Journal of Applied Physiology, 1973
- Mechanisms of Action of CO2 on Pial Precapillary VesselsEuropean Neurology, 1971
- The Mechanism of Action of Carbon Dioxide in the Regulation of Cerebral Blood FlowPublished by Elsevier ,1968
- Evidence for a Brain Stem Center Regulating CBFScandinavian Journal of Clinical and Laboratory Investigation, 1968
- CEREBRAL CIRCULATIONArchives of Neurology & Psychiatry, 1932