BIAS OF THE CONTRIBUTION OF SINGLE-LOCUS EFFECTS TO THE VARIANCE OF A QUANTITATIVE TRAIT
- 1 July 1986
- journal article
- research article
- Vol. 39 (1), 137-144
Abstract
Advances in our understanding of the physiology of many quantitative phenotypes combined with better measurement abilities is providing a means for pursuing a measured genotype approach to partitioning the phenotypic variance into the contribution of separate loci. The standard estimate of the contribution of a single locus to the phenotypic variance applied recently in the human genetics literature is a biased statistic. We compare the biased estimates from several published studies with biased corrected estimates to illustrate the general problem.This publication has 15 references indexed in Scilit:
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