Aluminum Hyoroxioe-Inouceo Osteomalacia, Encephalopathy ANO Hyperaluminemia in CAPO. Treatment with Oesferrioxamine

Abstract

We present the clinical course of a patient who has been treated with CAPD since 1979. He developed dialysis encephalopathy and fracturing osteomalacia, and was found to have a serum aluminum concentration of 560 μg/L. Treatment with desferrioxamine over a six month's period reduced his serum aluminum concentration to a non-toxic level, and his symptoms abated. One year after his initial encephalopathy this patient has a normal EEG, the bone fractures have healed, and serum aluminum concentration is 38 μg/ L. Apparently the hyperaluminemia was due to the ingestion of prescribed aluminum hydroxide.