In Vitro Evaluation of Antifungal Properties of 8.O.4‘-Neolignans
- 1 July 1997
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (7), 659-662
- https://doi.org/10.1021/np9605504
Abstract
Eighteen racemic 8.O.4‘-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (±)-erythro-3,4-(methylenedioxy)-7-hydroxy-1‘-allyl-3‘,5‘-dimethoxy-8.O.4‘-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.Keywords
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