Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase
- 15 November 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 176 (2), 595-598
- https://doi.org/10.1042/bj1760595
Abstract
Imidazole and compound L8027 (selective inhibitors of thromboxane synthase) produced parallel inhibition of malonaldehyde and thromboxane B2 secretion induced by collagen or thrombin in gel-filtered suspensions of human platelets. Comparing the effects of these inhibitors and aspirin on secretion of granule constituents indicated that platelet degranulation depends mainly on thromboxane production; prostaglandin endoperoxides contributed little.This publication has 16 references indexed in Scilit:
- Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandinsBiochemical Journal, 1978
- A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid Two selective thromboxane synthetase inhibitorsBiochimica et Biophysica Acta (BBA) - General Subjects, 1978
- Conversion of prostaglandin endoperoxides to C17‐hydroxy acids catalyzed by human platelet thromboxane synthaseFEBS Letters, 1977
- Simple, sensitive fluorimetric assay for malondialdehyde production by blood plateletsThrombosis Research, 1977
- Selective inhibition of thromboxane A2 biosynthesis in blood plateletsNature, 1977
- Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.Proceedings of the National Academy of Sciences, 1977
- THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGSBritish Journal of Pharmacology, 1977
- Malondialdehyde Production by Platelets during Secondary AggregationThrombosis and Haemostasis, 1977
- A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reactionBiochemical Journal, 1974
- Aggregation of Blood Platelets by Adenosine Diphosphate and its ReversalNature, 1962