The emphasis in publications relating to radiotherapy of cancer of the uterine cervix is on standard technics of intracavitary radium combined with parametrial external irradiation. The sharp gradient of dosage rate around the radioactive sources demands, to avoid areas of underdosage, optimal placement of the radioactive sources in relationship to disease. Local failures can be traced to cold spots (9). In this institution's clinical material, (M. D. Anderson Hospital and Tumor Institute, Houston, Texas) a significant percentage of cases are not best handled by standard technics, and many are even totally unsuited for primary intracavitary radium therapy. Megavoltage therapy has opened a new possibility of combining external irradiation and intracavitary radium therapy in the treatment of these patients. Whole pelvis irradiation of 4,000 rads in four weeks prior to intracavitary radium therapy can be used to advantage in selected cases of Stage I and Stage II cancers of the uterine cervix. Doses up to 6,000 rads can be given in six weeks, but, because of increased risk of complications, should be reserved, with exceptions, for Stage III and Stage IV cases. The analysis of 280 cases of Stages I and II (total number 1,002) treated from 1954 through December 1962 with this technic is reported with emphasis on the indications, results, complications, and feasibility of supplemental surgical procedures. In February 1959, the change from “roentgen” to “rad,” including other correction factors, increased the dosage by approximately 7 per cent. No adjustment was made in the treatment planning because previous analysis had shown that 4,000 roentgens in four weeks was well tolerated and a 7 per cent increase did not seem large enough to warrant adjustment. The patients treated prior to February 1959 received approximately 3,700 rads. Practically all patients have been treated with a 22 Mev betatron using 15 × 15 cm parallel opposing portals at a weekly rate of 1,000 roentgens prior to February 1959 and 1,000 rads since that time. In using whole-pelvis irradiation prior to intracavitary radium therapy, one wishes to include the disease on the cervix and vagina. The disease on the body surfaces is located with a caliper (4), and verification films are taken with the vaginal part of the caliper in situ. Unless vaginal disease is very low, 15 × 15 cm portals always include the entire length of the sacroiliac joints. Irradiation of this area is desired, as the hypogastric nodes and those around the bifurcation of the common iliac into the external iliac and hypogastric arteries, frequently involved by disease, are located in front of the sacroiliac joint (12). The entire rectum and rectosigmoid are unavoidably included in the irradiation fields.