The Effect of Preservation on the Behaviour of Homologous Ossicular Grafts

Abstract

The present study deals with the effect of several preservation methods on the behaviour of incus grafts in rats after orthotopic and heterotopic transplantations. The following conclusions can be drawn: 1. Preservation seems to influence both the potential for new bone formation and the antigenic properties of an ossicular graft. 2. Preservation in cialit and alcohol and freeze drying preserves the osteogenic properties to a variable extent. 3. Bone formation is absent after boiling and after preservation in formaldehyde. 4. The antigenic properties are affected by storage in alcohol and cialit and by boiling. 5. Preservation of the antigenic properties of the graft does occur after freezing and freeze drying and after storage in formaldehyde. 6. Typical reaction of transplantation and resorption of the graft are only observed after heterotopic transplantation in muscle.