SENSITIVE METHOD FOR DETERMINATION OF AMITRIPTYLINE AND NORTRIPTYLINE IN HUMAN-PLASMA
- 1 January 1976
- journal article
- research article
- Vol. 2 (2), 105-116
Abstract
A highly sensitive and reproducible GLC technique for the quantitation of amitriptyline and nortriptyline [tricyclic antidepressants] is described. The lower limit of detection is <1 ng/ml. Samples of 5 ng/ml (3 ml aliquots) can be accurately quantified (C of V [coefficient of variation] <5%). Steady state data are reported together with data on amitriptyline and nortriptyline levels obtained in a volunteer who ingested a single oral dose (25 mg) of amitriptyline (Elavil).This publication has 2 references indexed in Scilit:
- Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detectorAnalytical Chemistry, 1968
- APPLICATION OF ISOTOPE DERIVATIVE TECHNIQUE TO ASSAY OF SECONDARY AMINES - ESTIMATION OF DESIPRAMINE BY ACETYLATION WITH H3-ACETIC ANHYDRIDE1967