Iron-Catalyzed Kharasch-Type Reaction Between Grignard Reagents and Allylic Phosphates.Highly SN2 Selective Cross-Coupling Process

Abstract

Treatment of primary allylic phosphates in tetrahydrofuran with Grignard reagents in the presence of an iron catalyst gave cross-coupling products with high S_N2 selectivity. Among several phosphate leaving groups, diphenylphosphate ester showed the highest regioselectivity.