As early as 1900, Nicloux1found that in dogs about an hour after the ingestion of a single dose of alcohol the values in the blood and the spinal fluid were approximately equal. In 1913, Schumm and Fleischmann2administered a constant dose of alcohol to a series of patients, puncturing each patient at a different interval after ingestion and thereby obtaining a composite curve for the alcohol in the blood and in the spinal fluid. They found that during the first hour the alcohol in the blood rose more rapidly than that in the spinal fluid, but that during the decline of the alcohol in the blood the alcohol in the spinal fluid surpassed it and remained at a higher level. Because of Schumm and Fleischmann's use of single punctures for various patients, some of their figures fall far out of line. Recently, Abramson and Linde3repeated