Structural Factors Affecting Chiral Recognition and Separation on Cellulose Based Chiral Stationary Phases

Abstract
The structural factors and functional group selectivity requirements affecting direct high-performance liquid chromatographic enantiomeric resolution of drug racemates on several derivatized cellulose chiral stationary phases are reviewed. A guide for the choice of the appropriate chiral cellulose derivative column based on elements of asymmetry and functional groups of the compounds are presented.