Acetylation of Sulfanilamide and Para-Aminobenzoic Acid in Diabetic Patients

Abstract

CHARALAMPOUS and Hegsted¹ found that metabolic acetylation is impaired in experimental diabetes. They demonstrated this in alloxan-diabetic rats by the measurement of acetylated paraaminobenzoic acid (PABA) excreted in the urine after the intraperitoneal injection of PABA. It is known that this acetylation is carried out by acetyl coenzyme A. The present study was undertaken to ascertain whether such disturbances in acetylation occur in diabetic patients. Our results showed that no clearly significant impairment of acetylation is present in diabetes mellitus, in agreement with the findings of others.^{2 , 3} MethodNinety-two diabetic inpatients and 156 nondiabetic patients and healthy adults served as . . .