Dietary Cellulose, Zinc and Copper: Effects on Tissue Levels of Trace Minerals in the Rat
- 1 June 1979
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 109 (6), 1117-1122
- https://doi.org/10.1093/jn/109.6.1117
Abstract
This study was designed to examine the effect of graded levels of cellulose, zinc and copper on tissue mineral levels. Tissue mineral levels were assayed by atomic absorption spectrophotometry in samples collected from a study which involved 12 treatments in a 3 × 2 × 2 factorial arrangement. This study involved three levels of cellulose (0, 8, and 16% of the diet), two levels of Cu (deficient and adequate; 2 and 18 mg/kg of diet, respectively), and two levels of Zn (marginal and abundant; 10 and 120 mg/kg of diet, respectively). Six weanling, male Sprague-Dawley rats were assigned to each treatment and after 9 weeks they were killed. Reductions of tissue Cu content were observed in the serum, liver, tibia and testis of the rats fed the Cu-deficient diets. The Fe content of the tibia and testis was reduced, but that of liver was elevated in the rats fed Cu-deficient diets. Reductions in tibial Zn levels were observed in the rats fed marginal-Zn as compared to those fed the abundant-Zn diets; and in the rats fed Cu-adequate as compared to those fed Cu-deficient diets. Increases in cellulose resulted in increased liver and testicular Cu content only in rats fed the Cu-deficient diets. Additions of cellulose appeared to have no adverse effect on the distribution of Zn, Cu and Fe in tissues which are sensitive to dietary deficiencies. With the exception of rats fed the copper-deficient, marginal zinc diets, the rats fed the other diets demonstrated a small reduction in serum zinc values as cellulose was increased.Keywords
This publication has 11 references indexed in Scilit:
- Oxidation, Excretion, and Tissue Distribution of [26-14C] Cholesterol in Copper-Deficient RatsJournal of Nutrition, 1978
- Effects of Cellulose Added to Diets of Low and High Fiber Content upon the Metabolism of Calcium, Magnesium, Zinc and Phosphorus by ManJournal of Nutrition, 1977
- Other ElementsPublished by Elsevier ,1977
- Oral contraceptives, norethindrone and mestranol: effects on tissue levels of mineralsAmerican Journal of Physiology-Legacy Content, 1976
- Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingestedThe American Journal of Clinical Nutrition, 1973
- Relationships between copper, zinc and iron in the plasma, soft tissues and skeleton of the rat during Cu deficiencyBritish Journal of Nutrition, 1973
- EFFECT OF DIETARY FIBRE ON STOOLS AND TRANSIT-TIMES, AND ITS ROLE IN THE CAUSATION OF DISEASEThe Lancet, 1972
- Iron metabolism in copper-deficient ratsBritish Journal of Nutrition, 1971
- The role of ceruloplasmin in iron metabolismJCI Insight, 1970
- Studies on Zinc Deficiency: Changes in Trace Elements and Enzyme Activities in Tissues of Zinc-deficient Rats *JCI Insight, 1967