Use of chitosan for sustained-release preparations of water-soluble drugs.

Abstract

The applicability of chitosan as a vehicle for sustained-release preparations of H2O-soluble drugs was examined. Propranolol hydrochloride was selected as a model substance for this evaluation. Zero-order controlled release of propranolol hydrochloride from tablets containing chitosan was obtained in JP X disintegration medium No. 1 and in disintegration medium No. 2 following exposure to No. 1. Chitosan could be a useful vehicle for the controlled release of H2O-soluble drugs.