Ampicillin-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 8 (6), 819-831
- https://doi.org/10.3109/03639048209022127
Abstract
Differential scanning calorimetry was used as a screening technique for assessing the compatibility of anhydrous ampicillin with some of the direct compression excipients. Anhydrous ampicillin was found to be compatible with Avicel PH 101, Avicel PH 105, Elcema F 150, Elcema G 250, Sta-Rx 1500 and Cab-0-Sil, while incompatible with sorbitol, Di-Pac and dicalcium phosphate dihydrate. Anhydrous ampicillin appears to form complexes with mannitol, granular mannitol and Brownex sugar after their melting transitions. It appears that stearic acid and L-(-)-leucine can be used as lubricants in formulations containing anhydrous ampicillin while magnesium stearate cannot.This publication has 6 references indexed in Scilit:
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