CEVITAMIC ACID (ASCORBIC ACID; CRYSTALLINE VITAMIN C); A CRITICAL ANALYSIS OF ITS USE IN CLINICAL MEDICINE
- 30 September 1938
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 12 (4), 516-528
- https://doi.org/10.7326/0003-4819-12-4-516
Abstract
When test doses of 300-1000 mgm. were given orally, 30% was excreted in the urine in 24 hrs.; if 1000 mgm. was given intraven., 500 mgm. was normally excreted in 24 hrs.; 80% of the total 24-hrs. excretion took place in first 5 hrs. Capillary fragility tests, with a blood pressure cuff maintaining pressure for 15 mins. half way between systolic and diastolic, showed less than 10 petechiae normally in a 2.5 cm. circle on forearm. Preclinical scurvy is very common among all economic classes and in connection with many diseases e.g. rheumatic fever, whooping cough, osteomyelitis. The curative dosage is 30-50 mgm. daily.Keywords
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