Selective Targeting and Timing of Matrix Metalloproteinase Inhibition in Post-Myocardial Infarction Remodeling
- 7 October 2003
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 108 (14), 1753-1759
- https://doi.org/10.1161/01.cir.0000091087.78630.79
Abstract
Background— A cause-and-effect relationship exists between matrix metalloproteinase (MMP) induction and left ventricular (LV) remodeling after myocardial infarction (MI). Whether broad-spectrum MMP inhibition is necessary and the timing at which MMP inhibition should be instituted after MI remain unclear. This study examined the effects of MMP-1 and MMP-7-sparing inhibition (sMMPi) on regional and global LV remodeling when instituted before or after MI.Keywords
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