Asymmetric Wolff Rearrangement Reactions with α-Alkylated-α-diazoketones: Stereoselective Synthesis of α-Substituted-β-amino Acid Derivatives

Abstract

Photoinduced asymmetric Wolff rearrangement reactions were performed with α-amino-α‘-methyl-α‘-diazoketones to afford α-methyl-β-amino acid esters with good stereoselectivity. Factors that may influence the stereochemistry were examined, including steric effects and temperature dependence, which had a great impact on the stereochemistry.