Bioactive Bromophycolides R−U from the Fijian Red Alga Callophycus serratus
- 8 February 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 73 (2), 275-278
- https://doi.org/10.1021/np900686w
Abstract
Four new bromophycolides, R−U (1−4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.Keywords
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