Enhancement by TNF-? of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice
- 1 June 1995
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 140 (6), 987-992
- https://doi.org/10.1007/bf01315409
Abstract
The influence of tumor-necrosis-factor-α (TNF-α), granulocytemacrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-α and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon α/β (IFNα/β) prevented reactivation and replication.Keywords
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