Prevention of simian immunodeficiency virus, SIVsm, or HIV-2 infection in cynomolgus monkeys by pre- and postexposure administration of BEA-005
- 1 February 1997
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 11 (2), 157-162
- https://doi.org/10.1097/00002030-199702000-00004
Abstract
To study the possibilities and limitations of postexposure treatment to prevent the establishment of infection after accidental exposure to HIV. The effect of 2,3'-dideoxy-3'-hydroxymethyl cytidine (B1 A-005) was investigated on acute simian immunodeficiency virus (SIV) and HIV-2 infections in macaques in pre- and postexposure treatment experiments. Postexposure treatment with BLA-005 (3 x 10 mg/kg) for as short as 3 days prevented infection with SIVsm after intravenous or rectal inoculation. Infection with HIV-2 could also be blocked by postexposure BFA-005 treatment. This study shows that therapeutic intervention can block early systemic and mucosal infections with SIV and HIV-2. Further evaluation is ongoing.Keywords
This publication has 20 references indexed in Scilit:
- Protection against Mucosal SIVsmChallenge in Macaques Infected with a Chimeric SIV that Expresses HIV Type 1 EnvelopeAIDS Research and Human Retroviruses, 1996
- Incidence And Prevalence Of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C Virus, And Cytomegalovirus Among Health Care Personnel At Risk For Blood Exposure: Final Report From A Longitudinal StudyThe Journal of Infectious Diseases, 1994
- Prevention of HIV-2 and SIV Infections in Cynomolgus Macaques by Prophylactic Treatment with 3′-FluorothymidineAIDS Research and Human Retroviruses, 1992
- Early appearance of simian immunodeficiency virus (SIV) antigen and antibodies as variables in evaluating antiviral drugs in macaquesJournal of Virological Methods, 1992
- Clinical features and predictive markers of disease progression in cynomolgus monkeys experimentally infected with simian immunodeficiency virusAIDS, 1992
- Simian and feline immunodeficiency viruses: Animal lentivirus models for evaluation of AIDS vaccines and antiviral agentsAntiviral Research, 1991
- Synthesis of 2',3'-dideoxy-3'-C-hydroxymethyl nucleosides as potential inhibitors of HIVThe Journal of Organic Chemistry, 1991
- Vaccine Protection Against HIV-2 Infection in Cynomolgus MonkeysAIDS Research and Human Retroviruses, 1991
- Synthesis and Antiviral Evaluation of 3′-Branched Nucixoside AnaloguesNucleosides and Nucleotides, 1991
- Acute Infection of Cynomolgus Monkeys with Simian Immunodeficiency Virus (SIVSM) as a Model to Evaluate Antiviral Compounds. Effects of 3′-Azido, 3′-Deoxythymidine, Foscarnet and 2′,3′-DideoxycytidineAntiviral Chemistry and Chemotherapy, 1990