Glycosylation of low density lipoprotein in patients with Type I (insulin-dependent) diabetes: Correlations with other parameters of glycaemic control

Abstract

Glycosylation of low density lipoproteins obtained from 16 patients with Type 1 (insulin-dependent) diabetes and from 16 age-, sex-, and race-matched controls, was determined. The diabetic patients were normolipaemic and were in good or fair glycaemic control. Eleven patients performed home blood glucose monitoring. Glycosylation of low density lipoproteins in the diabetic patients was significantly higher (p < 0.001) than in the control subjects, and was significantly correlated with haemoglobin A_1c, (p < 0.01), glycosylation of plasma proteins, (p < 0.001), and mean home blood glucose, (p < 0.01). This study confirms that, in diabetic patients, increased glycosylation of low density lipoprotein occurs to an extent which correlates closely with other commonly used indices of glycaemic control.