Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury
- 12 July 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (1), 147-149
- https://doi.org/10.1212/01.wnl.0000167605.02541.f2
Abstract
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.Keywords
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