Multiple screening, the combining of several tests in a mass screening program, is described and compared as a case-finding technic in public health with screening for specific diseases. Multiple screening is termed a promising case-finding procedure, but it needs to be carefully developed and perfected before it can be routinely recommended as public health practice. When compared with screening for such diseases as syphilis and tuberculosis, many of the tests now included in the multi-test battery are not yet thoroughly validated nor are they backed up by adequate follow-up measures. Multiple screening may lose much of its potential value unless it is part of a well-developed control program. The other elements of a control program, such as diagnosis, follow-up, and treatment, must be developed along with case-finding.