Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function
Open Access
- 8 March 2010
- journal article
- Published by Springer Nature in Respiratory Research
- Vol. 11 (1), 28
- https://doi.org/10.1186/1465-9921-11-28
Abstract
Asthma is a chronic inflammatory disease of the airway that is characterized by a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The role of IL-6 in promoting effector T cell subsets suggest that IL-6 may play a functional role in asthma. Classically IL-6 has been viewed as an inflammatory marker, along with TNFα and IL-1β, rather than as regulatory cytokine.Keywords
This publication has 46 references indexed in Scilit:
- Lower Airway Disease in Asthmatics with and without RhinitisLung, 2008
- The effects of IL-6 on CD4 T cell responsesClinical Immunology, 2008
- The Biological Functions of T Helper 17 Cell Effector Cytokines in InflammationImmunity, 2008
- Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trialThe Lancet, 2008
- Systemic Inflammation and COPD: The Framingham Heart StudyChest, 2008
- Distinct regulation of interleukin‐17 in human T helper lymphocytesArthritis & Rheumatism, 2007
- Development, cytokine profile and function of human interleukin 17–producing helper T cellsNature Immunology, 2007
- Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cellsNature Immunology, 2007
- Interleukin-17 is a negative regulator of established allergic asthmaThe Journal of Experimental Medicine, 2006
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006