Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis
Open Access
- 1 May 1976
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 9 (5), 817-823
- https://doi.org/10.1128/aac.9.5.817
Abstract
Two alleles for viomycin-capreomycin resistance ( vic ) in Mycobacterium smegmatis affect ribosome structures. One ( vicA ) affects a component of 50 S subunits and the other ( vicB ) affects a component of 30 S subunits. The locus for neomycin-kanamycin resistance ( nek ), which is linked to vicA and vicB , affects a component of 30 S subunits. Although the erythromycin resistance locus ( ery ) is linked to vic and nek , no ribosomal alterations could be detected. Mutations at the streptomycin locus ( str ) not linked to vic and nek caused alterations of 30 S subunits.Keywords
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