LINKAGE BETWEEN A MARKER LOCUS AND A QUANTITATIVE TRAIT OF SIBS

Abstract

Several variations of a method for detecting linkage between a marker locus and a quantitative trait in full sib families are presented along with computational details. All variations are based on contrasts within qualifying families of 3 or more sibs. The empirical powers of the various test statistics, evaluated by simulation, were very similar, and also similar to that of Smith. These single-generation tests are likely to be successful only for many families and relatively tight linkage.