Effect of long‐term oral testosterone undecanoate treatment on prostate volume and serum prostate‐specific antigen concentration in eugonadal middle‐aged men

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Abstract
Testosterone undecanoate (160 mg/day) or placebo was given orally in a double‐blind fashion for 8 months to 23 middle‐aged men without urinary tract symptoms. Testosterone was found to increase the mean prostate volume by 12% (P < .012). The treatment suppressed the serum concentrations of sex‐hormone‐binding globulin and follicle stimulating hormone. The observed decrease in the mean serum concentration of luteinizing hormone was not statistically significant. The serum concentrations of prostate‐specific antigen did not change as measured by two different well‐validated immunometric assays. No changes in micturition habits or urine flow charts were reported.