A new antirheumatic drug, indomethacin, was evaluated over a long period of observation (42 months maximum). Clinically satisfactory results listed as both good and excellent were obtained in a high percentage of patients with ankylosing spondylitis, gouty polyarthritis, psoriatic arthritis, and other miscellaneous benign (nonfatal) rheumatic diseases. In rheumatoid arthritis, indomethacin produced good and excellent results in a lesser, though appreciable, percentage of cases and may be regarded as another valuable drug to be added to the overall program of therapy in this notably difficult disease. As indicated in the previous report, the experimental nature of this study required that in some cases the dosages be increased to and beyond tolerance. Therefore, therapy in private practice may not yield as high a percentage of favorable results as indicated in this report.