THE DIURETIC EFFECT OF GLOBIN IN CHRONIC GLOMERULONEPHRITIS

Abstract

In the management of the nephrotic state of chronic and subacute glomerulonephritis, edema offers a challenge to the attending physician. A salt-poor diet, moderate and carefully controlled water reduction, a protein intake sufficient not only to maintain a positive balance but also to restore progressively lost protein reserve, and proper cardiac stimulation if signs of insufficiency exist, are the basic elements of therapy.¹ These, however, are not always sufficient. It is often necessary to reduce or eliminate edema by means of diuretics. As diuretic agents urea, potassium chloride, ammonium chloride, mercurophylline injection (mercupurin), plasma, human serum albumin and globin have been used with varying degrees of success. Urea and mannitol, the first administered by mouth, the latter intravenously, are generally considered safe and should be tried, but their action is far from constant. Potassium chloride and ammonium chloride have been found to be effective but cannot be used in