Effects of starvation and Ca++ on glucose-induced accumulation of cyclic 3′,5′-AMP in pancreatic islets
- 1 February 1976
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (2), 155-157
- https://doi.org/10.1007/bf01937738
Abstract
Exposure to glucose in the presence of 3-isobutyl-1-methylxanthine leads to accumulation of cAMP in islets microdissected fromob/ob-mice. This process is dependent on extracellular Ca++ but differs markedly from the glucose action on insulin release in the same in vitro system in disappearing after 18 h of starvation.Keywords
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